INFLUENCE OF THE POLYMORPHIC MARKER T-786C OF THE ENOS3 GENE IN DIABETIC NEPHROPATHY

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Published: Dec 22, 2021
Keywords:
diabetic nephropathy diabetes mellitus nitric oxide synthase

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Jabbarov O. O
MD, DSc, Associate Professor, Head of the Department of Faculty and Hospital Therapy No.2, TMA
Sapayeva Z. A
Assistant of the Department of Internal Diseases and Dermatovenerology, Urgench branch of Tashkent medical academy, Uzbekistan

Abstract

This article presents the results of a study of 129 patients with type 2 diabetes and 110 healthy people to determine whether polymorphic T-786C markers of the ENOS3 gene are associated with the development of diabetic nephropathy. Patients in the main group: 65 patients with a disease duration of up to 10 years, without diabetic nephropathy (33 patients) and with diabetic nephropathy (32 patients), 64 patients with diabetes lasting more than 10-20 years, with no diabetic nephropathy (31 patients ) and diabetic nephropathy (33 patients). Genotyping was carried out by polymerase chain reaction. The study showed the association of the C allele and the СС genotype of the ENOS3 gene with a risk of developing diabetic nephropathy in patients with type 2 diabetes mellitus in the studied Uzbek nation.

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How to Cite
Jabbarov O. O, & Sapayeva Z. A. (2021). INFLUENCE OF THE POLYMORPHIC MARKER T-786C OF THE ENOS3 GENE IN DIABETIC NEPHROPATHY. Galaxy International Interdisciplinary Research Journal, 9(12), 893–898. Retrieved from https://giirj.com/index.php/giirj/article/view/821
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Vol. 9 No. 12 (2021): GIIRJ
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Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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