EVALUATION OF 12-WEEK URATE-REDUCING THERAPY WITH ALLOPURINOL IN COMBINATION WITH THE NONSTEROIDAL ANTI-INFLAMMATORY DRUG MELOXICAM IN PATIENTS WITH GOUT

Abstract

Gout or gouty arthritis is a rheumatic disease of a systemic nature, the cause of which is an increased content of uric acid in the blood (more than 6.8 mg / dl). The condition of arthritis develops due to the crystallization of sodium monaurate in the synovial fluid, followed by phagocytosis and the formation of inflammasomes. It is the latter that are the main mechanism of systemic inflammation. Gout, what kind of disease it is and how to deal with it – you need to know, especially if a bone began to bother your leg. It appears in the area of the thumb joint. Among rheumatic pathologies, gout ranks second after osteoporosis. The disease occurs more often in men than in women. Hyperuricemia can be caused by excessive intake of purine bases into the body, the product of the decay of which it is. And they come mainly with food: red varieties of meat and fish, coffee, cocoa and chocolate, cheeses, sausages, smoked meats, alcoholic beverages. Incontinence in the use of these products inevitably leads to the deposition of urates in the tissues. In ancient times, not everyone could afford the abuse of such products, which is why gout was called the "disease of the aristocrats", because its presence indicated a certain level of well-being. The relationship between the development of gout, the severity of its signs and the volume of treatment in men with nutrition, or rather its imbalance and irrationality is obvious. With the increase in the standard of living of the population, the incidence of this disease has also increased – gout has truly been the misfortune of overeating humanity, whereas in third world countries it is quite rare.